Engineering of an Hepatic Organoid to Develop Liver Assist Devices

Left Ventricular Assist Devices: Engineering Design Considerations

Patients with end-stage congestive heart failure awaiting heart transplantation often wait long periods of time (300 days or more on the average) before a suitable donor heart becomes available. The medical community has placed increased emphasis on the use of Left Ventricular Assist Devices or LVADs that can substitute for, or enhance, the function of the natural heart while the patient is wai...

Stem Cell Organoid Engineering

Organoid systems leverage the self-organizing properties of stem cells to create diverse multicellular tissue proxies. Most organoid models only represent single or partial components of a tissue, and it is often difficult to control the cell type, organization, and cell-cell/cell-matrix interactions within these systems. Herein, we discuss basic approaches to generate stem cell-based organoids...

An Engineering Approach to Develop Business Networks

Organoid technologies meet genome engineering.

Three-dimensional (3D) stem cell differentiation cultures recently emerged as a novel model system for investigating human embryonic development and disease progression in vitro, complementing existing animal and two-dimensional (2D) cell culture models. Organoids, the 3D self-organizing structures derived from pluripotent or somatic stem cells, can recapitulate many aspects of structural organ...

Basic knowledge of interest Bioengineering of liver assist devices

urine. Hepatocytes, which are the predominant cell type within the liver, account for two-thirds of the liver mass. The liver is normally able to regenerate after acute injury and regain its function under appropriate physiological stimuli.1 However, when the normal regenerative process is compromised and the residual functional capacity of the damaged liver is unable to sustain life, liver fai...